Pepperoni Pizza Grilled Cheese

Category: Family Dinner Ideas

This comforting sandwich brings together melty mozzarella, tangy marinara, and delicious pepperoni for a quick and satisfying meal. Thick-cut bread is buttered and grilled to golden perfection, encasing a warm, gooey cheese filling that bursts with classic pizza flavors. Perfect for lunch or dinner, it’s ready in just 15 minutes and easy to make for all skill levels. Pair with a side salad or enjoy solo for a truly delectable treat. It’s a fusion of pizza flavors and classic grilled cheese simplicity.

Fatiha
By Fatiha Fatiha
Last updated Thu, 19 Feb 2026 13:30:46 GMT
A stack of pepperoni sandwiches. Pin
A stack of pepperoni sandwiches. | zestplate.com

This pepperoni pizza grilled cheese is a quick and delightful twist on two classics. Its perfectly crisp golden bread paired with gooey melted mozzarella, flavorful marinara, and savory pepperoni makes it a go-to choice for an easy dinner or comforting snack.

I created this when my craving for pizza met the simplicity of a grilled cheese and now it is a favorite for lazy Sunday lunches.

Ingredients

  • Thick-cut sandwich bread: Gives that hearty structure you need for the perfect grilled cheese. Select fresh but firm bread for the best results.
  • Shredded or sliced mozzarella cheese: Melts beautifully to create that stretchy cheese pull. Fresh mozzarella takes it up a notch in flavor and creaminess.
  • Pepperoni: Adds the signature pizzeria flavor in every bite. Choose a high-quality variety for the best taste.
  • Marinara or pizza sauce: Keeps it all moist and brings the pizza vibes to life. Aim for a rich flavorful marinara.
  • Softened butter: Ensures the bread crisps up evenly without burning. Use real butter for unmatched flavor.

How To Make Pepperoni Pizza Grilled Cheese

Prepare the bread and sauce:
Spread the marinara sauce generously on one side of each bread slice, ensuring it is even.
Build the layers:
Lay mozzarella cheese on the sauce side of one bread slice. Add a layer of pepperoni slices and, for extra cheesiness, top with more mozzarella.
Assemble the sandwich:
Place the second slice of bread on top with the sauce side facing inward. Ensure the layers are aligned properly.
Butter the bread:
Gently spread softened butter on both outer sides of the sandwich to ensure crispiness.
Grill until perfect:
Heat a skillet over medium heat. Cook the sandwich slowly for 4 to 5 minutes per side until the bread is golden while flipping carefully.
A pepperoni sandwich on a wooden table.
A pepperoni sandwich on a wooden table. | zestplate.com

I love using fresh mozzarella here because the stretch as you bite into the sandwich takes me right back to a childhood love for melty cheese pizza.

Serving Suggestions

Pair your grilled cheese with a side of extra marinara for dipping to enhance the pizza experience. Add a light salad on the side to balance out the richness of the sandwich and make it a complete meal. This also works wonderfully with a bowl of tomato soup for ultimate comfort on rainy afternoons.

Ingredient Substitutions

  • For a smoother texture, use sliced mozzarella over shredded.
  • Switch up the protein by using turkey pepperoni for a leaner option or try a vegetarian version by substituting roasted vegetables like mushrooms or zucchini for the pepperoni.
  • A pinch of Italian seasoning sprinkled over the cheese before grilling adds a burst of herby aroma.
A stack of pepperoni sandwiches.
A stack of pepperoni sandwiches. | zestplate.com

Storage Tips

While these sandwiches are best fresh off the skillet, they can be refrigerated wrapped tightly in foil for up to 2 days. Reheat in a skillet for the best texture. Avoid using a microwave as it may make the bread soggy.

Recipe FAQs

→ Can I use a different type of cheese?

Yes, you can substitute mozzarella with provolone, cheddar, or a blend of Italian cheeses for a twist!

→ What bread works best for this sandwich?

Thick-cut sandwich bread or sourdough is ideal for achieving a crispy crust and holding the filling together.

→ Can I make this without butter?

You can use olive oil or a non-stick pan spray as an alternative to butter for grilling the bread.

→ What can I serve with this sandwich?

A side salad, potato chips, or a bowl of tomato soup pairs wonderfully with this sandwich.

→ Can I use turkey pepperoni instead of regular pepperoni?

Absolutely! Turkey pepperoni is a great alternative if you're looking for a leaner option.

→ How can I reheat leftover sandwiches?

Reheat leftovers in a skillet or toaster oven to maintain crispness. Avoid microwaving as it may make the bread soggy.

Pepperoni Pizza Grilled Cheese

Golden bread, gooey cheese, and pepperoni for a comforting, melty sandwich.

Preparation Time
5 min
Cooking Time
10 min
Total Duration
15 min
By Fatiha: Fatiha

Category: Main Dishes

Skill Level: Easy

Cuisine: American

Output: 2 Servings (2 sandwiches)

Dietary Preferences: ~

Ingredients

→ Sandwich Ingredients

01 4 slices thick-cut sandwich bread
02 1/2 cup shredded or sliced mozzarella cheese
03 12 slices pepperoni
04 2 tablespoons marinara or pizza sauce
05 2 tablespoons softened butter

Directions

Step 01

Spread marinara or pizza sauce on one side of each slice of bread.

Step 02

Layer mozzarella cheese on one slice of bread, add pepperoni, and top with additional cheese if desired.

Step 03

Close the sandwich with the second slice of bread, ensuring the sauce side faces inward.

Step 04

Spread softened butter on the outer sides of each assembled sandwich.

Step 05

Heat a skillet over medium heat and grill the sandwiches for 3-4 minutes on each side until the bread is golden and the cheese has melted.

Notes

  1. For an extra crispy crust, press the sandwich slightly with a spatula while grilling.

Required Equipment

  • Skillet
  • Spatula

Allergen Information

Review each component for possible allergens and consult a health professional when concerned.
  • Contains dairy from mozzarella and butter.
  • Contains gluten from sandwich bread.

Nutritional Information (per serving)

These figures serve as estimates and are not a substitute for medical advice.
  • Calories: 450
  • Fat: 27.3 g
  • Carbohydrates: 40.5 g
  • Protein: 16.8 g