Garlic Parmesan Chicken Spaghetti

Category: Family Dinner Ideas

Indulge in a hearty and flavorful Garlic Parmesan Chicken Spaghetti dish. This recipe combines tender chicken breast strips, perfectly cooked spaghetti, and a creamy Cajun-style sauce made with mozzarella, sharp cheddar, and cream cheese. The addition of garlic, Italian seasoning, and dried basil creates a harmonious symphony of flavors, while the subtle heat from the Cajun spices ties everything together beautifully. Serve up this delicious pasta dish for a comforting meal that is sure to impress your diners.

Fatiha
By Fatiha Fatiha
Last updated Wed, 11 Mar 2026 14:18:27 GMT
A plate of pasta with garlic on top. Pin
A plate of pasta with garlic on top. | zestplate.com

This Garlic Parmesan Chicken Spaghetti in Spicy Three-Cheese Cajun Cream Sauce is a family favorite that brings a restaurant-quality meal right to your table. The creamy, cheesy sauce paired with tender chicken and spaghetti is a dinner that satisfies every craving, perfect for busy weeknights or indulgent weekends.

I first created this recipe when I craved something hearty yet elevated for a weeknight dinner. My family couldn’t get enough, and it has since become one of our most requested dishes.

Ingredients

  • Large boneless, skinless chicken breasts: Sliced into thin strips adds protein while cooking quickly and evenly
  • Spaghetti: Serves as the base bringing everything together. Choose high-quality spaghetti for a better texture
  • Low-sodium chicken broth: Creates the base of the sauce without overpowering the flavor. Opt for a high-quality brand
  • Shredded mozzarella: Melts effortlessly for a creamy and stringy texture
  • Shredded sharp cheddar: Adds a bold flavor. Look for fresh cheddar for maximum taste
  • Cream cheese: Softened adds creaminess creating a silky-smooth sauce without lumps
  • Italian seasoning: Provides a blend of herbs for added depth
  • Dried basil: Enhances the dish with subtle earthy notes

How To Make Garlic Parmesan Chicken Spaghetti in Spicy Three-Cheese Cajun Cream Sauce

Sauté the Chicken:
Cook the strips of chicken in a large skillet over medium heat until golden and cooked thoroughly about 8 to 10 minutes. Set aside and keep warm.
Boil the Pasta:
Cook the spaghetti according to the package instructions until al dente. Reserve half a cup of pasta water before draining.
Prepare the Cream Sauce:
In the same skillet used for the chicken, add low-sodium chicken broth and bring it to a simmer. Gradually whisk in the mozzarella, cheddar, cream cheese, Italian seasoning, and dried basil. Stir until smooth and creamy ensuring no lumps remain.
Combine Everything:
Toss the cooked spaghetti and chicken in the prepared sauce, adding reserved pasta water as needed to adjust consistency. Let it cook for another 3 to 5 minutes allowing the flavors to meld.
Serve:
Plate up the spaghetti and chicken topping with freshly grated Parmesan if desired. Enjoy warm.
A plate of food with garlic on it.
A plate of food with garlic on it. | zestplate.com

Mozzarella is my favorite in this recipe for the way it melts into pure creaminess. I also have memories of making this sauce with my little ones who loved to help stir the ingredients together around the stove.

Storage Tips

Store leftovers in an airtight container in the refrigerator for up to three days. Reheat gently on the stove with a splash of additional chicken broth to loosen up the sauce.

Ingredient Substitutions

You can swap spaghetti for linguine or even fettuccine if preferred. For a lighter cheese option try part-skim mozzarella or reduced-fat cream cheese.

Serving Suggestions

Pair this dish with a simple green salad and a side of crusty garlic bread. The fresh crunch from a salad complements the creamy richness perfectly.

A plate of food with chicken and pasta.
A plate of food with chicken and pasta. | zestplate.com

Making flavorful meals with minimal effort is what makes this recipe so enjoyable and timeless whether you want to impress dinner guests or enjoy a cozy night in with your family.

Recipe FAQs

→ Can I use a different type of pasta?

Yes, you can substitute spaghetti with fettuccine, linguine, or penne for a similar texture and taste.

→ Can I make this dish less spicy?

Reduce the amount of Cajun seasoning or use a milder seasoning blend to adjust the spice level to your preference.

→ What can I use instead of chicken breasts?

Boneless, skinless chicken thighs work well as an alternative, offering a slightly richer flavor and more tender texture.

→ Can I make this dish ahead of time?

You can prepare the sauce and cook the chicken ahead of time. Store them separately and combine them with freshly cooked pasta when ready to serve.

→ Is it possible to make this dish gluten-free?

Yes, simply use gluten-free pasta and double-check that your Cajun seasoning and cheeses are gluten-free.

→ How can I store the leftovers?

Store the leftovers in an airtight container in the refrigerator for up to 3 days. Reheat gently on the stovetop or in the microwave.

Garlic Parmesan Chicken Spaghetti

Tender chicken with spaghetti in Cajun three-cheese garlic cream sauce.

Preparation Time
15 min
Cooking Time
25 min
Total Duration
40 min
By Fatiha: Fatiha

Category: Main Dishes

Skill Level: Intermediate

Cuisine: Cajun

Output: 4 Servings

Dietary Preferences: ~

Ingredients

→ Poultry

01 2 large boneless, skinless chicken breasts, sliced into thin strips

→ Pasta

02 12 oz spaghetti

→ Sauce Ingredients

03 ¾ cup low-sodium chicken broth
04 1 cup shredded mozzarella
05 1 cup shredded sharp cheddar
06 2 oz cream cheese, softened
07 ½ tsp Italian seasoning
08 ½ tsp dried basil

Directions

Step 01

Slice the chicken breasts into thin strips and season as desired. Heat oil in a skillet over medium heat and cook the chicken until fully cooked and golden brown, about 5-7 minutes.

Step 02

Bring a large pot of salted water to a boil. Add the spaghetti and cook according to package instructions until al dente. Drain and set aside.

Step 03

In the same skillet used for the chicken, add low-sodium chicken broth and bring to a simmer. Stir in cream cheese until smooth. Gradually incorporate shredded mozzarella and sharp cheddar, stirring constantly until melted and fully combined. Add Italian seasoning and dried basil to taste.

Step 04

Add the cooked spaghetti to the skillet with the Cajun cream sauce. Toss to coat the pasta thoroughly.

Step 05

Add the cooked chicken strips back to the skillet and gently toss to combine with the pasta and sauce. Serve hot.

Required Equipment

  • Large skillet
  • Large pot
  • Spatula
  • Colander

Allergen Information

Review each component for possible allergens and consult a health professional when concerned.
  • Dairy
  • Wheat (gluten)

Nutritional Information (per serving)

These figures serve as estimates and are not a substitute for medical advice.
  • Calories: 685.5
  • Fat: 32.8 g
  • Carbohydrates: 45.3 g
  • Protein: 49.6 g